全文获取类型
收费全文 | 294130篇 |
免费 | 4280篇 |
国内免费 | 818篇 |
学科分类
工业技术 | 299228篇 |
出版年
2021年 | 2565篇 |
2019年 | 2307篇 |
2018年 | 4077篇 |
2017年 | 4024篇 |
2016年 | 4363篇 |
2015年 | 2799篇 |
2014年 | 4725篇 |
2013年 | 12782篇 |
2012年 | 7555篇 |
2011年 | 10041篇 |
2010年 | 8177篇 |
2009年 | 9227篇 |
2008年 | 9468篇 |
2007年 | 9242篇 |
2006年 | 8190篇 |
2005年 | 7614篇 |
2004年 | 7048篇 |
2003年 | 6776篇 |
2002年 | 6843篇 |
2001年 | 6619篇 |
2000年 | 6293篇 |
1999年 | 6274篇 |
1998年 | 14699篇 |
1997年 | 10898篇 |
1996年 | 8336篇 |
1995年 | 6532篇 |
1994年 | 5917篇 |
1993年 | 5791篇 |
1992年 | 4434篇 |
1991年 | 4415篇 |
1990年 | 4242篇 |
1989年 | 4245篇 |
1988年 | 4200篇 |
1987年 | 3563篇 |
1986年 | 3576篇 |
1985年 | 4116篇 |
1984年 | 3919篇 |
1983年 | 3570篇 |
1982年 | 3382篇 |
1981年 | 3518篇 |
1980年 | 3389篇 |
1979年 | 3327篇 |
1978年 | 3418篇 |
1977年 | 3882篇 |
1976年 | 5024篇 |
1975年 | 3122篇 |
1974年 | 2976篇 |
1973年 | 2998篇 |
1972年 | 2628篇 |
1971年 | 2439篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Michael A. Clegg Prof. Nicholas C. O. Tomkinson Dr. Rab K. Prinjha Dr. Philip G. Humphreys 《ChemMedChem》2019,14(4):362-385
The bromodomain and extra terminal (BET) family of bromodomain-containing proteins (BCPs) have been the subject of extensive research over the past decade, resulting in a plethora of high-quality chemical probes for their tandem bromodomains. In turn, these chemical probes have helped reveal the profound biological role of the BET bromodomains and their role in disease, ultimately leading to a number of molecules in active clinical development. However, the BET subfamily represents just 8/61 of the known human bromodomains, and attention has now expanded to the biological role of the remaining 53 non-BET bromodomains. Rapid growth of this research area has been accompanied by a greater understanding of the requirements for an effective bromodomain chemical probe and has led to a number of new non-BET bromodomain chemical probes being developed. Advances since December 2015 are discussed, highlighting the strengths/caveats of each molecule, and the value they add toward validating the non-BET bromodomains as tractable therapeutic targets. 相似文献
32.
Nurullah Bulut Bahar Atmaca Gülsün Akdemir Evrendilek Sibel Uzuner 《Journal of Food Safety》2020,40(6):e12855
Seed processing technologies are essential for seed safety and functionality through protection of physicochemical quality, pathogen inactivation, aflatoxin detoxification and alleviation of mutagenicity. Design of a pilot-scale unit of pulsed electric fields (PEF) to treat sesame seeds with respect to quality parameters, Aspergillus parasiticus inactivation and aflatoxin reduction as well as alleviation of aflatoxin mutagenicity were prompted in this study. PEF energy ranged from 0.97 to 17.28 J achieved maximum reductions of peroxide value and acidity number of 67.4 and 85.7%, respectively, and did not change color L*, a*, b* and hue values. A 60% reduction of A. parasiticus counts occurred at the maximum PEF energy. Aflatoxins G1, G2, B1, and B2 contents decreased by 94.7, 92.7, 86.9, and 98.7%, respectively. Except for the samples treated by 2.16 J with 100 μg/plate and by 6.80 J with 10 μg/plate, PEF treatment provided elimination of aflatoxin mutagenity. It is concluded that PEF treatment can be used to treat sesame seeds with preservation of physicochemical properties, inactivation of A. parasiticus and decomposition of aflatoxins with reduced mutagenicity. 相似文献
33.
Bianka Rocha Saraiva Lucas Henrique Maldonado da Silva Fernando Antônio Anjo Ana Carolina Pelaes Vital Jéssica Bassi Da Silva Marcos Luciano Bruschi Paula Toshimi Matumoto Pintro 《International Journal of Food Science & Technology》2020,55(5):1962-1970
Debittered trub (brewing waste) is an important source of protein source (70.26%). Trub and whey protein were used for 5% protein enrichment of ice cream frozen by liquid nitrogen. Three formulations were elaborated: ice cream standard (ICS), ice cream with whey protein (ICW) and ice cream with trub (ICT). Chemical composition, rheological properties, texture, overrun, melting rate, scanning electron microscopy and a sensorial test were performed. Results showed that ICT presented a higher viscosity, obtained on the upward curve up to 6.76 Pa s−1, consistency index (22.96 (Pa s−1)n), hysteresis area (140.40 mPa s−1) and hardness (31113.33 g) but a lower melting rate (0.38 g min−1), overrun (13.92%) and sensorial acceptability than the other formulations. The addition of trub debittered for protein enrichment improved ice cream properties and demonstrated that it could be used as a food ingredient. 相似文献
34.
Simonov M. Yu. Pertsev A. S. Shaimanov G. S. Simonov Yu. N. 《Metal Science and Heat Treatment》2020,61(9-10):601-609
Metal Science and Heat Treatment - The structure, the strength characteristics and the impact toughness at different temperatures up to –100°C of tubular billets from steel 35 are... 相似文献
35.
Theoretical Foundations of Chemical Engineering - The extraction of nitric and oxalic acids by neutral compounds TBP, DBBP, and TBPO have been studied. The optimal conditions of their separation... 相似文献
36.
37.
38.
39.
40.